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Micah Fomichev
Micah Fomichev

K Theory - Boundaries (Trap VIP) ((NEW))



In humans, keloids are also a common complication characterized as hypertrophic dermal elements. The collagen content of keloids consists of type III and type I collagen fibers while hypertrophic scars consist of mostly type III collagen [543,544]. Additionally, hypertrophic scars appear shortly after injury and may reduce in size over time, while keloid development may lag, and their size can extend beyond the boundaries of the original wound. Both keloids and hypertrophic scars require TGFβ [545]. Crosstalk between keratinocytes and fibroblasts has been implicated in a previous in vitro study in which keloid-derived fibroblasts induced the expansion of co-cultured keratinocytes [546].




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